The connection between transcription and genomic instability
نویسندگان
چکیده
منابع مشابه
Does interference between replication and transcription contribute to genomic instability in cancer cells?
We have recently reported that topoisomerase 1 (Top1) cooperates with ASF/SF2, a splicing factor of the SR family, to prevent unscheduled replication fork arrest and genomic instability in human cells. Our results suggest that Top1 execute this function by suppressing the formation of DNA-RNA hybrids during transcription, these so-called R-loops interfering with the progression of replication f...
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Replication and transcription are key aspects of DNA metabolism that take place on the same template and potentially interfere with each other. Conflicts between these two activities include head-on or co-directional collisions between DNA and RNA polymerases, which can lead to the formation of DNA breaks and chromosome rearrangements. To avoid these deleterious consequences and prevent genomic...
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ژورنال
عنوان ژورنال: The EMBO Journal
سال: 2002
ISSN: 0261-4189
DOI: 10.1093/emboj/21.3.195